


The Health Dangers of Antibiotic Overuse
by Dr. Mercola in Gut Health Posted on 01/10/2013 12:00 AM
STORY AT-A-GLANCE
Antibiotic-resistant disease is a major threat to public health, and the primary cause for this man-made epidemic is the widespread misuse of antibiotics—both in medicine and agriculture
Recent research shows children whose mothers took antibiotics during their pregnancy were more likely to develop asthma. Children predisposed to asthma were twice as likely to develop asthma if their mother used antibiotics during the third trimester, compared to those whose mother did not use antibiotics
A baby gets his or her first "inoculation" of gut flora from the mother’s birth canal during childbirth, which is why a mother’s use of antibiotics during pregnancy may predispose the child to asthma and a variety of other ailments, including neurological dysfunction and autoimmune disorders
One chicken farmer has demonstrated that even large-scale animal farming can manage without routine administration of antibiotic drugs by using an herbal remedy of oregano oil and cinnamon instead
You can help yourself and your community by using antibiotics only when absolutely necessary and by purchasing organic, antibiotic-free meats and other foods. Natural compounds with antibiotic/antiviral activity include oil of oregano, garlic, and Echinacea, which you can try before resorting to drugs
By Dr. Mercola
The issue of antibiotic overuse, both in medicine and food production, and the subsequent threats to human health, has been featured in a number of recent news articles.
According to the European Centre for Disease Prevention and Control (ECDC), antibiotic resistance is a major threat to public health, worldwide, and the primary cause for this man-made epidemic is the widespread misuse of antibiotics.
For example, data from the ECDC1 shows a significant rise of resistance to multiple antibiotics in Klebsiella pneumoniae and E. coli in just the last four years alone, affecting more than one-third of the EU. According to a recent report by Medical News Today:2
"In several of the member states, between 25 and over 60 percent of K pneumoniae from bloodstream infections show combined resistance to multiple antibiotics...
The ECDC data shows that consumption of carbapenems, a major class of last-line antibiotics, went up significantly in EU/EEA countries between 2007 and 2010. The report suggests this is most likely due to increasing multidrug resistance in Gram-negative infections, such as pneumonia or bloodstream infections, which are often treated with carbapenems."
In an effort to raise awareness, the UK has issued an informational leaflet3 on the judicious use of antibiotics, urging patients to not ask their doctors for an antibiotic to treat symptoms of cold and flu, as antibiotics do not work on infections caused by viruses — they only work on bacterial infections.
Antibiotics During Pregnancy Linked to Asthma in Kids
Antibiotic-resistant disease is not the only danger associated with the misuse of these drugs. Excessive exposure to antibiotics also takes a heavy toll on your gastrointestinal health, which can predispose you to virtually any disease. Abnormal gut flora may actually be a major contributing factor to the rise in a wide variety of childhood diseases and ailments.
For example, recent research4 from Denmark shows that children whose mothers took antibiotics during their pregnancy were more likely to develop asthma, compared to those whose mother did not take antibiotics. Taking other risk factors into account, the researchers estimated that children exposed to antibiotics were 17 percent more likely to be hospitalized for asthma before the age of five.
Children who were already predisposed to asthma (due to their mother having the condition) were twice as likely to develop asthma if their mother used antibiotics during the third trimester, compared to those whose mother did not use antibiotics.
While the study cannot tell us whether the asthma was the result of the antibiotic or the infection itself, the increased asthma risk found does support the theory that probiotics — beneficial bacteria residing in your gut, which are decimated by antibiotics — play a role in the development of asthma. Co-author Dr. Hans Bisgaard told Reuters Health:5
"We speculate that mothers' use of antibiotics changes the balance of natural bacteria, which is transmitted to the newborn, and that such unbalanced bacteria in early life impact on the immune maturation in the newborn."
Indeed, one of the most important prerequisites for your newborn is establishing a healthy gastrointestinal tract. Regardless of age, your gut is your first line of defense in terms of immunity.
The baby gets his or her first "inoculation" of gut flora from the mother's birth canal during childbirth, which is why a mother's use of antibiotics during pregnancy can predispose the child to asthma and a variety of other ailments, as the antibiotic severely disrupts the natural microflora — in the mother's bowels and vagina.
It's important to understand that if mother's flora is abnormal, her baby's flora will also be abnormal, as whatever organisms live in her vagina end up coating her baby's body and lining his or her intestinal tract.
Antibiotic Use May Predispose Your Baby to GAPS
The introduction of unfriendly flora can predispose your baby to GAPS (Gut and Psychology Syndrome, and also Gut and Physiology Syndrome). GAPS can have very damaging long-term effects on a child's health, both neurologically and physiologically. Besides an increased risk of asthma and other allergies, it can also increase his or her risk of learning and/or behavioral disabilities, mood disorders, gastrointestinal problems, and autoimmune disorders.
GAPS may even have profound implications for the autism epidemic. Rates of childhood autism are staggering, now 50 times higher in some areas than three decades ago. Not surprisingly, there is a matching epidemic of GAPS.
Dr. Natasha Campbell-McBride is a neurologist and neurosurgeon who has devoted years of her career to studying this phenomenon, and how to treat and prevent it. She's convinced that abnormal gut flora is at the heart of the problem, and that the solution to stem the rise in autistic spectrum disabilities lies in "healing and sealing" the child's gut. As a result of her groundbreaking research, she has developed a very effective nutritional protocol for doing just that. To learn more, please review my previous articleHow a Physician Cured Her Son's Autism.
The Importance of Probiotic Foods
The widespread deterioration of people's gut health can be traced back to the change in our modern diet. Historically, people have regularly consumed a wide variety of fermented foods, which are naturally high in the beneficial bacteria necessary for optimal gut health. Fermented foods are therefore a mainstay of the GAPS diet. Ideally, you'll want to include a variety of cultured foods and beverages in your diet, as each food will inoculate your gut with a variety of different microorganisms. Fermented foods you can easily make at home include:
Fermented vegetables
Chutneys
Condiments, such as salsa and mayonnaise
Cultured dairy, such as yoghurt, kefir, and sour cream
Fish, such as mackerel and Swedish gravlax
The beneficial bacteria in these foods are also potent detoxifiers, capable of drawing out a wide range of toxins and heavy metals. According to Dr. McBride, the GAPS Nutritional Protocol restores the detoxification system in about 90 percent of people, and the fermented/cultured foods are instrumental in this self-healing process. You don't need to consume huge amounts either. Just a quarter to a half a cup of fermented vegetables or cultured food such as raw yoghurt, per day, is sufficient. Kombucha, a fermented drink, is another great addition to your diet.
The key is variety. The greater the variety of fermented and cultured foods you include in your diet, the better, as each food will inoculate your gut with a variety of different microorganisms. Also remember to always reseed your gut with probiotics whenever you're using an antibiotic, either by consuming fermented foods, or taking a high quality probiotics supplement.
In the following interview, Caroline Barringer, a Nutritional Therapy Practitioner (NTP), and an expert in the preparation of the foods prescribed in Dr. Campbell-McBride's GAPS nutritional program, discusses the process of fermenting your own vegetables.
It's actually easier than you might think, and it can save you a lot of money. It's unusual to find a probiotic supplement containing more than 10 billion colony-forming units. But when my team actually tested fermented vegetables produced by probiotic starter cultures, they had 10 trillion colony-forming units of bacteria. Literally, one serving of fermented vegetables was equal to an entire bottle of a high potency probiotic! So clearly, you're far better off using fermented foods.
If you fear the culturing process might lead to some horrific pathogenic infection, please read Caroline's article "Taking the Mystery out of Culturing Your Own Superfoods,"6 where she lays such fears to rest. Educating yourself about the process will help alleviate concerns about eating fermented foods, which are very much "alive."
Are Antibiotics Really Necessary in Food Production?
As mentioned earlier, antibiotic overuse occurs not just in medicine, but also in food production. In fact, agricultural uses account for about 80 percent of all antibiotic use in the US,7 so it's a MAJOR source of human antibiotic consumption. Animals are often fed antibiotics at low doses for disease prevention and growth promotion, and those antibiotics are transferred to you via meat, and even via the manure used as crop fertilizer.
Protecting your gut health and reducing the spread of antibiotic-resistant bacteria are significant reasons for making sure you're only eating grass-fed, organically-raised meats and animal products.
Example of Typical CAFO Hen House
In a related news story, one farmer demonstrates that even large-scale animal farming can manage without routine administration of antibiotic drugs. Chicken farmer Scott Sechler, owner of Bell & Evans, tells the New York Times8 how an old-fashioned herbal remedy to keep his flocks healthy:
"Off and on over the last three years or so, his chickens have been eating a specially milled diet laced with oregano oil and a touch of cinnamon. Mr. Sechler swears by the concoction as a way to fight off bacterial diseases that plague meat and poultry producers without resorting to antibiotics, which some experts say can be detrimental to the humans who eat the meat.
Products at Bell & Evans, based in this town about 30 miles east of Harrisburg, have long been free of antibiotics, contributing to the company's financial success as consumers have demanded purer foods.But Mr. Sechler said that nothing he had used as a substitute in the past worked as well as oregano oil. 'I have worried a bit about how I'm going to sound talking about this,' he said. 'But I really do think we're on to something here.'"
Interestingly, the oregano product Mr. Sechler uses has been tested against four drugs made by Bayer, comparing its ability to control diarrhea in piglets caused by E.coli. The oregano product, sold under the name By-O-Reg Plus, outperformed all four Bayer products.
"'Strange but true!' Dr. Lucio Nisoli, the Bayer product manager, wrote in his report on the trial. 'Compared to the various anti-infectives, with Ropadiar I have obtained much more effective and quicker results. Furthermore, piglets treated with Ropadiar look much more healthy and were not so dehydrated and wasted,'" the New York Times writes.9
Many Natural Compounds have Antibiotic Activity, Without the Side Effects
You can help yourself and your community by using antibiotics only when absolutely necessary and by purchasing organic, antibiotic-free meats and other foods. Even though the problem of antibiotic-resistance needs to be stemmed through public policy on a nationwide level, the more people who get involved on a personal level to stop unnecessary antibiotic use the better...If you live in the United States and want to get involved on a national level, Food Democracy Now! has created apetition against the overuse of antibiotics in livestock production.10 If you care about this issue, I suggest you use this petition to make your voice heard.
Also, to bring us back to where we began, please make sure to avoid unnecessary use of antibiotics during pregnancy. Not every bacterial infection needs to be treated with a drug. First, as an all-around preventive measure, you'll want to make sure your vitamin Dlevel is optimized year-round, especially during pregnancy, along withvitamin K2. But there are also a number of natural compounds that act as broad-based antibiotics/anti-virals that you can try first, such as:
Oreganol (oil of oregano)
Garlic
Echinacea
Manuka honey (for topical application)
Hurry — Deadline to Join New Project to Learn About YOUR Gut Bacteria is Fast Approaching
Lastly, I'd like to remind you about what I believe is one of the most important natural health projects of this century —The American Gut Project,11 which I recently discussed in greater detail. The project, which is open to the public, will allow participants to learn more about their gut — which microbes inhabit your intestines, and how they might be affecting your health.
But hurry — the deadline to participate is February 2.
It's an extremely ambitious project seeking to identify the parameters for the ideal gut bacteria, and how diet affects it. I am personally participating in this project, and I'm very excited to see what consuming several ounces of fermented vegetables nearly every day has done to my bowel flora. Jeff Leach, an anthropologist and now graduate student at the London School of Hygiene & Tropical Medicine and a co-founder of the Project recently told Prevention Magazine:12
"We hope to enter the national conversation about what you should eat. Our question is this: From the perspective of your gut microbiome, which may be linked to many acute and chronic diseases, what diet should you follow?"
To learn more, and for instructions on how to participate, please see the article: "American Gut" - One of the Most Important Health Projects of the 21st Century.
Sources and References
1 European Centre for Disease Prevention and Control
2 Medical News Today November 19, 2012
3 Antibiotic Information Leaflet
4 The Journal of Pediatrics, Published Online November 8, 2012
5 Reuters Health November 19, 2012
6 Taking the Mystery Out of Culturing Your Own Superfoods
7 Food Safety News February 24, 2011
8 New York Times December 25, 2012
9 See ref 8
10 Food Democracy Now! Petition to stop industrial meat’s antibiotic abuse

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