By Dr. Mercola

So you're carrying some extra weight around, what's the easiest and healthiest way to get rid of it? Many believe the answer lies in burning off more calories than you're taking in, and while this theory sounds reasonable, the reality is more complex.

Many also believe that cutting fat from their diet is an essential step, but this too is a myth1 that may actually prevent you from achieving the weight loss you seek.

It's important to realize that you cannot exercise your way out of a poor diet. Research2 shows exercise is largely ineffective for producing any significant amount of weight loss on its own.

Part of this is because while you certainly burn more calories when you exercise, you cannot burn off thousands of excess calories each day.

For example, to burn off the calories from a Snickers bar you'd have to walk about five miles, and to offset a one -soda-per-day habit, you have to walk one hour per day just to prevent additional weight gain...

The good news is, weight loss can be achieved by virtually everyone, once you understand a few core concepts. A successful weight loss plan can be broken down into three easy-to-remember components:3

When it comes to weight loss, high-intensity interval training (HIIT) combined with intermittent fasting is the most effective combo I know of.

According to the American College of Sports Medicine,6 HIIT workouts tend to burn anywhere from 6 to 15 percent more calories compared to other workouts, and intermittent fasting helps "reset" your body to start burning fat rather than sugar as its primary fuel.

When done together, they create a powerful synergy that effectively sheds body fat and promotes optimal metabolic function.

The human body evolved performing very high-intensity activities for brief periods of time, and this kind of activity appears to be part and parcel of our genotype. When recreating this ancestral activity, you have plenty of options these days.

For example, you can perform high-intensity exercises on an exercise bike or elliptical machine, or take the high-intensity route to strength training. To learn more, please see "Why High-Intensity Workouts Are Best for Weight Loss."

According to the calorie myth, in order to lose weight all you need to do is follow the equation of "eat less, move more." But, while these statements may sound valid, it will not work unless you get certain details right.

A key piece of information is that all calories are not created equal. You can eat more calories and lose weight, or eat fewer calories and still gain weight. Your weight is affected by the source of the calories, not just the number of calories. Zoe Harcombe's book, The Obesity Epidemic, is one of the most comprehensive documents I've ever seen that exposes the flaws of this myth.

Research by Dr. Robert Lustig has also shredded this dogmatic belief, showing that not even calories fromdifferent kinds of sugar (such as glucose and fructose) are treated identically by your body.

Refined fructose is actually broken down very much like alcohol, damaging your liver and causing mitochondrial and metabolic dysfunction in the same way as ethanol and other toxins, whereas glucose does not wreak this kind of metabolic havoc.

According to Dr. Lustig, fructose is "isocaloric but not isometabolic." What this means is that identical calorie counts from fructose or glucose, fructose and protein, or fructose and fat, will cause entirely different metabolic effects.

So, when it comes to cutting calories, it's important to discern which calories will promote health and which ones will sabotage it. Simply going on a low-cal diet in which you ditch calorie-rich fats and/or opt for artificially sweetened products is not going to do you any favors whatsoever. As recently noted in The New York Times:7

Even if you do initially lose weight on a low-fat diet, you're sacrificing your long-term health by promoting insulin resistance and related diseases for the simple reason that low-fat diets tend to be high in sugars instead. For example, a recent meta-review9 published in the Mayo Clinic Proceedings found that once you reach 18 percent of your daily calories from added sugar, there's also a two-fold increase in metabolic harm that promotes pre-diabetes and diabetes.

More often than not, you'll find that the weight comes off much easier when you eat more healthy fats and less non-vegetable carbohydrates (added sugars, processed fructose, and processed grains). If all of this sounds complicated, don't fret; it's actually quite easy to figure this out once you grasp and memorize the basics.

In a nutshell, all you really need to remember is that processed foods contain loads of ingredients that promote metabolic dysfunction, insulin resistance, and obesity, so the key is to eat REAL food. The following chart will provide a few more clarifying details:

Foods that promote weight gain

Most people have been indoctrinated to equate saturated fats with heart disease, but there's really no evidence supporting this notion. On the contrary, an overwhelming amount of recent research has effectively dispelled this myth. Not only do saturated fats not promote heart disease, you actually need saturated fats for brain and immune system health.

Moreover, many vitamins, such as vitamins A, D, E, and K are fat-soluble, and you have to have fat in order to absorb those vitamins from your food. Many also don't realize that processed foods labeled as "low-fat" typically contain massive amounts of added sugars or artificial sweeteners instead. Start reading the labels and you'll soon realize that the fat is simply traded for sugar, and that's what's really packing on the pounds...

Studies refuting the notion that saturated fats are bad for you include the following:

• A meta-analysis12,13,14,15 published in the British Medical Journal (BMJ), found no association between high levels of saturated fat in the diet and heart disease. Nor could they find an association between saturated fat consumption and other life-threatening diseases like stroke or type 2 diabetes. However, the study DID find a disease link to trans fat consumption.

Trans fats were linked to a 28 percent increased risk for death from coronary heart disease, and a 34 percent increased risk of all-cause mortality. This is important because many "experts" frequently confuse trans fat with saturated fat intake.

• A pooled analysis of 11 studies16,17 showed that replacing saturated fat (found in foods like meat, egg yolks, dairy products, salmon, nuts, avocados, coconut oil, and olive oil) with monounsaturated fat (vegetable cooking oils),18 or

carbohydrates (sugars and grains) raised the risk of non-fatal heart attacks. This prompted the authors to comment that dietary guidelines for saturated fats and trans fats "must carefully consider the effect of replacement nutrients." This too is in line with previous findings, including this next one.

• In a 2014 editorial19 published in the Open Heart journal, research scientist and doctor of pharmacy James J. DiNicolantonio reviewed the cardiometabolic consequences of replacing saturated fats with carbohydrates, warning that the health consequences of doing so include:

✓ Shift to overall atherogenic lipid profile (lower HDL, increased triglycerides, and increased ApoB/ApoA-1 ratio)

✓ Increased risk of coronary heart disease, cardiovascular events, and death from heart disease and increased overall mortality (all causes)

✓ Increased thrombogenic markers

✓ Increased oxidized LDL

✓ Increased inflammation

✓ Reduced HDL

✓ Impaired glucose tolerance, higher body fat, weight gain, obesity, and diabetes

✓ Increased small, high-density LDL particles

✓ Increased risk for cancer

There's compelling evidence suggesting that when you eat morning, noon, and night, you increase your risk for both obesity and diabetes. Not only does this continuous grazing tend to lead to overeating in general, it also causes biological changes that result in metabolic dysfunction and subsequent weight gain and diminished health.

Our ancestors did not have access to food 24/7, and from a historical perspective it appears your body was designed for intermittent periods of fasting. In fact, a number of beneficial effects take place when you go for periods of time without eating. For the last couple of years, I've suggested anintermittent fastingschedule that limits meals to a narrow window of six to eight hours a day — ideally by skipping breakfast, and having lunch be your first meal.

However, some people really struggle without breakfast, and I've more recently come to realize that you can skip breakfast or dinner — as long as you skip one of them. The key to remember is to only eat within a window of six to eight consecutive hours each day, and avoiding food for at least three hours before bedtime. However, due to the way your body generates energy from mitochondria production explained below, I am not convinced that it's ideal to skip dinner. Another alternative is to have a very light meal as early as possible.

Eating too close to bedtime is another meal-timing factor that can sabotage your health. It's important to have a minimum of three hours after your last food intake before you go to bed. Ideally, aim for as much as six hours between your last meal and your scheduled bedtime.

The rationale for this recommendation has to do with the way your body produces energy. Your mitochondria are responsible for "burning" the fuel your body consumes and converting it into usable energy. These tiny bacterial derivatives live inside your cell and are optimized to create energy from the food you eat and the oxygen in the air you breathe. Your cells have between 100 and 100,000 mitochondria.

Your mitochondria have a series of electron transport chains in which they pass electrons from the reduced form of the food you eat to combine it with oxygen from the air you breathe to form water. This process drives protons across the mitochondrial membrane, which recharges ATP (adenosine triphosphate) from ADP (adenosine diphosphate). ATP is the carrier of energy throughout your body.

A major side effect of this transfer of electrons is that some leak from the electron transport chain to react with oxygen to form the free radical superoxide. Superoxide anion, the product of a one electron reduction of oxygen, is the precursor of most reactive oxygen species and a mediator in oxidative chain reactions. These oxygen free radicals attack the lipids in your cell membranes, protein receptors, enzymes, and DNA that can prematurely kill your mitochondria.

Please understand that some free radicals are actually good and your body requires them to regulate cellular function. The problem is when you have excessive free radical production. Sadly that is the case for the majority of the population and why most diseases, especially cancers, are acquired. There are two possible solutions, increase your antioxidants or reduce mitochondrial free radical production.

I believe one of the best strategies for reducing mitochondrial free radical production is to limit the amount of fuel you feed your body when it requires the least amount, which is when you are sleeping. If you feed your body shortly before sleeping you will have large amounts of fuel your body simply has no need for, which will result in a massive increase in leakage of electrons that combine with oxygen to form free radicals, which damage your DNA, and thereby radically increases your risk of cancer.

This is one of the reasons why I rarely eat less than three hours before going to bed and frequently it is 5 to 6 hours. A review paper20 that provides much of the experimental work for the above explanation was published in 2011, titled "Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies."

It may be too complex for many laypeople, but the take-home message is that since your body uses the least amount of calories when sleeping, you'll want to avoid eating close to bedtime because adding excess fuel at this time will generate excessive free radicals that will damage your tissues, accelerate aging, and contribute to chronic disease.

Sources and References

1 Authority Nutrition October 2015

2 Obesity June 2007: 15(6); 1496-1512

3 Business Insider August 11, 2015

4 Epoch Times October 19, 2015

5 New York Times October 19, 2015

6 American College of Sports Medicine, High Intensity Interval Training (PDF

7 New York Times September 23, 2015

8 New York Times September 2, 2014

9 Mayo Clinic Proceedings March 2015: 90(3); 372-381

10 Nutrition and Diabetes (2015) 5, e172

11 Nutritionfacts.org August 13, 2015

12, 16 BMJ 2015;351:h3978

13 Reuters August 12, 2015

14 Foodnavigator-usa.com August 12, 2015

15 Medical News Today August 12, 2015

17 American Journal of Clinical Nutrition February 11, 2009: 89(5); 1425-1432

18 Nutrition Data, Foods Highest in Monounsaturated Fat

19 Open Heart 2014;1: doi:10.1136/openhrt-2013-000032

20 Journal of Aging Research 2011 Article ID 807108